Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 (SOD2) in Pulmonary Arterial Hypertension: a basis for excessive cell proliferation and a new therapeutic target

BACKGROUND: Excessive proliferation and impaired apoptosis of pulmonary artery smooth muscle cells (PASMC) contributes to vascular obstruction in patients and fawn-hooded rats (FHR) with pulmonary arterial hypertension (PAH). Expression and activity of mitochondrial superoxide dismutase-2 (SOD2), th...

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Main Authors: Archer, Stephen L., Marsboom, Glenn, Kim, Gene H., Zhang, Hannah J., Toth, Peter T., Svensson, Eric C., Dyck, Jason R.B., Gomberg-Maitland, Mardi, Thébaud, Bernard, Husain, Aliya N., Cipriani, Nicole, Rehman, Jalees
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914302/
https://ncbi.nlm.nih.gov/pubmed/20529999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.916098
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