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Balancing Cell Migration with Matrix Degradation Enhances Gene Delivery to Cells Cultured Three-Dimensionally Within Hydrogels

In regenerative medicine, hydrogels are employed to fill defects and support the infiltration of cells that can ultimately regenerate tissue. Gene delivery within hydrogels targeting infiltrating cells has the potential to promote tissue formation, but the delivery efficiency of nonviral vectors wit...

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Bibliografiske detaljer
Main Authors: Shepard, Jaclyn A., Huang, Alyssa, Shikanova, Ariella, Shea, Lonnie D.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914156/
https://ncbi.nlm.nih.gov/pubmed/20450944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2010.04.032
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