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Microwave-assisted Organic Synthesis of a High-affinity Pyrazolo-pyrimidinyl TSPO Ligand

We herein report a dramatically improved total synthesis of the high-affinity translocator protein (TSPO) ligand DPA-714, featuring microwave-assisted organic synthesis (MAOS). Compared with previously described approaches, our novel MAOS method dramatically reduces overall reaction time without adv...

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Autores principales: Tang, Dewei, Buck, Jason R., Hight, Matthew R., Manning, H. Charles
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913893/
https://ncbi.nlm.nih.gov/pubmed/20689673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2010.06.074
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