The High-Mobility Group A1a/Signal Transducer and Activator of Transcription-3 Axis: An Achilles Heel for Hematopoietic Malignancies?

Although HMGA1 (high-mobility group A1; formerly HMG-I/Y) is an oncogene that is widely overexpressed in aggressive cancers, the molecular mechanisms underlying transformation by HMGA1 are only beginning to emerge. HMGA1 encodes the HMGA1a and HMGA1b protein isoforms, which function in regulating ge...

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Autors principals: Hillion, Joelle, Dhara, Surajit, Sumter, Takita Felder, Mukherjee, Mita, Di Cello, Francescopaolo, Belton, Amy, Turkson, James, Jaganathan, Souyma, Cheng, Linzhao, Ye, Zhaohui, Jove, Richard, Aplan, Peter, Lin, Ying-Wei, Wertzler, Kelsey, Reeves, Ray, Elbahlouh, Ossama, Kowalski, Jeanne, Bhattacharya, Raka, Resar, Linda M. S.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913892/
https://ncbi.nlm.nih.gov/pubmed/19074878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2121
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