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Permissive Secondary Mutations Enable the Evolution of Influenza Oseltamivir Resistance
The His(274)→Tyr(274) (H274Y) mutation confers oseltamivir resistance on N1 influenza neuraminidase but had long been thought to compromise viral fitness. However, beginning in 2007–2008, viruses containing H274Y rapidly became predominant among human seasonal H1N1 isolates. We show that H274Y decre...
Tallennettuna:
| Päätekijät: | , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2010
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2913718/ https://ncbi.nlm.nih.gov/pubmed/20522774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1187816 |
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