Protease polymorphisms in HIV-1 subtype CRF01_AE represent selection by antiretroviral therapy and host immune pressure

BACKGROUND: Most of our knowledge about how antiretrovirals and host immune responses influence the HIV-1 protease gene is derived from studies of subtype B virus. We investigated the effect of protease resistance-associated mutations (PRAMs) and population-based HLA haplotype frequencies on polymor...

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Main Authors: Manosuthi, Weerawat, Butler, David M., Pérez-Santiago, Josué, Poon, Art F.Y., Pillai, Satish K., Mehta, Sanjay R., Pacold, Mary E., Richman, Douglas D., Pond, Sergei Kosakovsky, Smith, Davey M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913588/
https://ncbi.nlm.nih.gov/pubmed/20009919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e3283350eef
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