Suppression of integrin α3β1 in breast cancer cells reduces COX-2 gene expression and inhibits tumorigenesis, invasion, and crosstalk to endothelial cells

Integrin receptors for cell adhesion to extracellular matrix have important roles in promoting tumor growth and progression. Integrin α3β1 is highly expressed in breast cancer cells where it is thought to promote invasion and metastasis; however, its roles in regulating malignant tumor cell behavior...

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Hauptverfasser: Mitchell, Kara, Svenson, Kimberly B., Longmate, Whitney M., Gkirtzimanaki, Katerina, Sadej, Rafal, Wang, Xianhui, Zhao, Jihe, Eliopoulos, Aristides G., Berditchevski, Fedor, DiPersio, C. Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913124/
https://ncbi.nlm.nih.gov/pubmed/20631072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4283
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