A Pegylated Growth Hormone Receptor Antagonist, Pegvisomant, Does Not Enter the Brain in Humans

Background: GH receptors exist in the hippocampus, cerebral cortex, and hypothalamus, possibly influencing mood, cortical blood flow, and neuronal growth and mediating negative feedback. Rationale: Pegvisomant is a recombinant mutated GH molecule with high affinity, but little or no activating capab...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Veldhuis, Johannes D., Bidlingmaier, Martin, Bailey, Joy, Erickson, Dana, Sandroni, Paola
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Endocrine Society 2010
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913040/
https://ncbi.nlm.nih.gov/pubmed/20444908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2010-0538
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