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Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule

BACKGROUND: Different isoforms of Cytochrome P450 (CYP) metabolized different types of substrates (or drugs molecule) and make them soluble during biotransformation. Therefore, fate of any drug molecule depends on how they are treated or metabolized by CYP isoform. There is a need to develop models...

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Detalhes bibliográficos
Main Authors: Mishra, Nitish K, Agarwal, Sandhya, Raghava, Gajendra PS
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912882/
https://ncbi.nlm.nih.gov/pubmed/20637097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2210-10-8
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