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Simultaneous gene silencing of Bcl-2, XIAP and Survivin re-sensitizes pancreatic cancer cells towards apoptosis

BACKGROUND: Pancreatic ductal adenocarcinoma shows a distinct apoptosis resistance, which contributes significantly to the aggressive nature of this tumor and constrains the effectiveness of new therapeutic strategies. Apoptosis resistance is determined by the net balance of the cells pro-and anti-a...

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書誌詳細
主要な著者: Rückert, Felix, Samm, Nicole, Lehner, Anne-Kathrin, Saeger, Hans-Detlev, Grützmann, Robert, Pilarsky, Christian
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912871/
https://ncbi.nlm.nih.gov/pubmed/20646298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-379
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