Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors

BACKGROUND: Activating mutations in Kit receptor tyrosine kinase or the related platelet-derived growth factor receptor (PDGFR) play an important role in the pathogenesis of gastrointestinal stromal tumors (GIST). METHODS: This study investigated the activity of motesanib, an inhibitor of vascular e...

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Autori principali: Caenepeel, Sean, Renshaw-Gegg, Lisa, Baher, Angelo, Bush, Tammy L, Baron, Will, Juan, Todd, Manoukian, Raffi, Tasker, Andrew S, Polverino, Anthony, Hughes, Paul E
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912835/
https://ncbi.nlm.nih.gov/pubmed/20633291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-29-96
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