Acid Activation of Trpv1 Leads to an Up-Regulation of Calcitonin Gene-related Peptide Expression in Dorsal Root Ganglion Neurons via the CaMK-CREB Cascade: A Potential Mechanism of Inflammatory Pain

Increased production of calcitonin gene-related peptide (CGRP) in sensory neurons is implicated in inflammatory pain. The inflammatory site is acidic due to proton release from infiltrating inflammatory cells. Acid activation of peripheral nociceptors relays pain signals to the CNS. Here, we examine...

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Main Authors: Nakanishi, Masako, Hata, Kenji, Nagayama, Tomotaka, Sakurai, Teruhisa, Nishisho, Toshihiko, Wakabayashi, Hiroki, Hiraga, Toru, Ebisu, Shigeyuki, Yoneda, Toshiyuki
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912344/
https://ncbi.nlm.nih.gov/pubmed/20534813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-01-0049
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