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Ion permeation and block of the gating pore in the voltage sensor of Na(V)1.4 channels with hypokalemic periodic paralysis mutations

Hypokalemic periodic paralysis and normokalemic periodic paralysis are caused by mutations of the gating charge–carrying arginine residues in skeletal muscle Na(V)1.4 channels, which induce gating pore current through the mutant voltage sensor domains. Inward sodium currents through the gating pore...

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Bibliografski detalji
Glavni autori: Sokolov, Stanislav, Scheuer, Todd, Catterall, William A.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912069/
https://ncbi.nlm.nih.gov/pubmed/20660662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201010414
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