Genetic profile for five common variants associated with age-related macular degeneration in densely affected families: a novel analytic approach

About 40% of the genetic variance of age-related macular degeneration (AMD) can be explained by a common variation at five common single-nucleotide polymorphisms (SNPs). We evaluated the degree to which these known variants explain the clustering of AMD in a group of densely affected families. We so...

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Main Authors: Sobrin, Lucia, Maller, Julian B, Neale, Benjamin M, Reynolds, Robyn C, Fagerness, Jesen A, Daly, Mark J, Seddon, Johanna M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911949/
https://ncbi.nlm.nih.gov/pubmed/19844262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2009.185
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