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Psychological Stress-Induced, IDO1-Dependent Tryptophan Catabolism: Implications on Immunosuppression in Mice and Humans

It is increasingly recognized that psychological stress influences inflammatory responses and mood. Here, we investigated whether psychological stress (combined acoustic and restraint stress) activates the tryptophan (Trp) catabolizing enzyme indoleamine 2,3-dioxygenase 1(IDO1) and thereby alters th...

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Detalhes bibliográficos
Main Authors: Kiank, Cornelia, Zeden, Jan-Philip, Drude, Solveig, Domanska, Grazyna, Fusch, Gerhard, Otten, Winfried, Schuett, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911374/
https://ncbi.nlm.nih.gov/pubmed/20689575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011825
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