An Improved Bicistronic CD20/tCD34 Vector for Efficient Purification and In Vivo Depletion of Gene-Modified T Cells for Adoptive Immunotherapy

T-cell-based adoptive immunotherapy is widely used to treat graft rejection and relapse after stem cell transplantation (SCT). However, this approach is hampered by a high risk of life-threatening graft-versus-host-disease (GvHD). Clinical trials have demonstrated the value of suicide genes to modif...

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Detalhes bibliográficos
Main Authors: Vogler, Isabel, Newrzela, Sebastian, Hartmann, Sylvia, Schneider, Nadine, von Laer, Dorothee, Koehl, Ulrike, Grez, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911262/
https://ncbi.nlm.nih.gov/pubmed/20461062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.83
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