Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

OBJECTIVE: Insulin resistance is commonly associated with obesity. Studies conducted in obese mouse models found that endoplasmic reticulum (ER) stress contributes to insulin resistance, and treatment with tauroursodeoxycholic acid (TUDCA), a bile acid derivative that acts as a chemical chaperone to...

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Detalhes bibliográficos
Main Authors: Kars, Marleen, Yang, Ling, Gregor, Margaret F., Mohammed, B. Selma, Pietka, Terri A., Finck, Brian N., Patterson, Bruce W., Horton, Jay D., Mittendorfer, Bettina, Hotamisligil, Gökhan S., Klein, Samuel
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911053/
https://ncbi.nlm.nih.gov/pubmed/20522594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0308
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