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Enhanced generation of Alzheimer's amyloid-β following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C

Alzheimer's amyloid precursor protein (APP) sorting and processing are modulated through signal transduction mechanisms regulated by protein phosphorylation. Notably, protein kinase C (PKC) appears to be an important component in signaling pathways that control APP metabolism. PKCs exist in at...

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Detalhes bibliográficos
Main Authors: da Cruz e Silva, Odete A. B., Rebelo, Sandra, Vieira, Sandra I., Gandy, Sam, da Cruz e Silva, Edgar F., Greengard, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911029/
https://ncbi.nlm.nih.gov/pubmed/19012746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2008.05770.x
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