Cytokine Overproduction, T-Cell Activation, and Defective T-Regulatory Functions Promote Nephritis in Systemic Lupus Erythematosus

Lupus nephritis (LN) occurs in more than one-third of patients with systemic lupus erythematosus. Its pathogenesis is mostly attributable to the glomerular deposition of immune complexes and overproduction of T helper- (Th-) 1 cytokines. In this context, the high glomerular expression of IL-12 and I...

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Bibliographic Details
Main Authors: Tucci, Marco, Stucci, Stefania, Strippoli, Sabino, Silvestris, Francesco
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2010
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910555/
https://ncbi.nlm.nih.gov/pubmed/20671931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/457146
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