A Common PCSK9 Haplotype, Encompassing the E670G Coding Single Nucleotide Polymorphism, Is a Novel Genetic Marker for Plasma Low-Density Lipoprotein Cholesterol Levels and Severity of Coronary Atherosclerosis

OBJECTIVES: We sought to determine the effects of PCSK9 variants on plasma low-density lipoprotein cholesterol (LDL-C) levels, severity of coronary atherosclerosis, and response to statin therapy in the Lipoprotein Coronary Atherosclerosis Study (LCAS) population. BACKGROUND: Mutations in PCSK9 caus...

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Main Authors: Chen, Suet N., Ballantyne, Christie M., Gotto, Antonio M., Tan, Yanli, Willerson, James T., Marian, Ali J.
Format: Artigo
Jezik:Inglês
Izdano: 2005
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910256/
https://ncbi.nlm.nih.gov/pubmed/15893176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2005.01.051
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