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Omeprazole preferentially inhibits the metabolism of (+)-(S)-citalopram in healthy volunteers

AIM: The study assessed the influence of omeprazole on the kinetic disposition of the (+)-(S)-citalopram (CITA) and (−)-(R)-CITA enantiomers in healthy volunteers. METHODS: In a cross-over study, healthy volunteers (n = 9) phenotyped as extensive metabolizers of CYP2C19 and CYP2D6 and with an oral m...

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Bibliografiske detaljer
Main Authors: Rocha, Adriana, Coelho, Eduardo B, Sampaio, Stefânia A, Lanchote, Vera L
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909806/
https://ncbi.nlm.nih.gov/pubmed/20642546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03649.x
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