Targeted Immunotherapy with Rituximab Leads to a Transient Alteration of the IgG Autoantibody Profile in Pemphigus Vulgaris

In pemphigus vulgaris (PV), IgG autoantibodies against the ectodomain of desmoglein 3 (Dsg3) have been shown to be directly responsible for the loss of keratinocyteadhesion. The aim of the present study was to study the effect of the B cell depleting anti-CD20 monoclonal antibody, rituximab, on the...

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Main Authors: Müller, Ralf, Hunzelmann, Nicolas, Baur, Vera, Siebenhaar, Guido, Wenzel, Elke, Eming, Rüdiger, Niedermeier, Andrea, Musette, Philippe, Joly, Pascal, Hertl, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909726/
https://ncbi.nlm.nih.gov/pubmed/20671975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/321950
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