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Toward high-resolution homology modeling of antibody F(v) regions and application to antibody-antigen docking

High-resolution homology models are useful in structure-based protein engineering applications, especially when a crystallographic structure is unavailable. Here, we report the development and implementation of RosettaAntibody, a protocol for homology modeling of antibody variable regions. The proto...

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Hlavní autoři: Sivasubramanian, Arvind, Sircar, Aroop, Chaudhury, Sidhartha, Gray, Jeffrey J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909601/
https://ncbi.nlm.nih.gov/pubmed/19062174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22309
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