Serine/Threonine Kinase Akt Activation Regulates the Activity of Retinal Serine/Threonine Phosphatases, PHLPP and PHLPPL

In our previous studies we have shown that insulin receptor (IR) activation leads to the activation of phosphoinositide 3-kinase (PI3K) and Akt activation in rod photoreceptors. This pathway is functionally important for photoreceptor survival as deletion of IR and one of the isoforms of Akt (Akt2)...

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Bibliographic Details
Main Authors: Kanan, Yogita, Matsumoto, Hiroyuki, Song, Hongman, Sokolov, Maxim, Anderson, Robert E., Rajala, Raju V.S.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909469/
https://ncbi.nlm.nih.gov/pubmed/20089132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.06609.x
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