Immune regulatory effects of simvastatin on regulatory T cell-mediated tumour immune tolerance

Statins are potent inhibitors of hydroxyl-3-methylglutaryl co-enzyme A (HMG-CoA) reductase, and have emerged as potential anti-cancer agents based on preclinical evidence. In particular, compelling evidence suggests that statins have a wide range of immunomodulatory properties. However, little is kn...

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Bibliographic Details
Main Authors: Lee, K J, Moon, J Y, Choi, H K, Kim, H O, Hur, G Y, Jung, K H, Lee, S Y, Kim, J H, Shin, C, Shim, J J, In, K H, Yoo, S H, Kang, K H
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2010
Subjects:
Translational Studies
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909412/
https://ncbi.nlm.nih.gov/pubmed/20491794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2010.04170.x
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