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Use of Transdermal Melatonin Delivery to Improve Sleep Maintenance during Daytime

Oral melatonin can improve daytime sleep, but the hormone's short elimination half-life limits its use as a hypnotic in shift workers, jet-lag and other situations. Here we show in healthy subjects that transdermal delivery of melatonin during the daytime can elevate plasma melatonin and reduce...

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Autors principals: Aeschbach, D, Lockyer, BJ, Dijk, D-J, Lockley, SW, Nuwayser, ES, Nichols, LD, Czeisler, CA
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909186/
https://ncbi.nlm.nih.gov/pubmed/19606092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2009.109
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