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Morphological analysis of 13 LMNA variants identified in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy

BACKGROUND: Mutations in the LMNA gene, encoding lamins A/C, represent a significant cause of dilated cardiomyopathy (DCM). We recently identified 18 protein-altering LMNA variants in a cohort of 324 unrelated patients with DCM. However, at least one family member with DCM in each of six pedigrees l...

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Autores principales: Cowan, Jason, Li, Duanxiang, Gonzalez-Quintana, Jorge, Morales, Ana, Hershberger, Ray E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908895/
https://ncbi.nlm.nih.gov/pubmed/20160190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.109.905422
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