Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression

BACKGROUND: The anaplastic lymphoma kinase (ALK) gene is frequently involved in translocations that lead to gene fusions in a variety of human malignancies, including lymphoma and lung cancer. Fusion partners of ALK include NPM, EML4, TPM3, ATIC, TFG, CARS, and CLTC. Characterization of ALK fusion p...

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Autors principals: Zhang, Xuchao, Zhang, Shirley, Yang, Xuening, Yang, Jinji, Zhou, Qing, Yin, Lucy, An, Shejuan, Lin, Jiaying, Chen, Shiliang, Xie, Zhi, Zhu, Mike, Zhang, Xiaolin, Wu, Yi-long
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908583/
https://ncbi.nlm.nih.gov/pubmed/20624322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-188
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