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Identification and Functional Characterization of a Stable, Centrally Active Derivative of the Neurotensin (8–13) Fragment as a Potential First-in-Class Analgesic

The neurotensin hexapapetide fragment NT(8–13) is a potent analgesic when administered directly to the central nervous system, but does not cross the blood brain barrier. A total of 43 novel derivatives of NT(8–13) were evaluated with one, ABS212 (1), being most active in four rat models of pain whe...

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Detalhes bibliográficos
Main Authors: Hughes, Francis M., Shaner, Brooke E., May, Lisa A., Zotian, Lyndsay, Brower, Justin O., Woods, R. Jeremy, Cash, Michael, Morrow, Dustin, Massa, Fabienne, Mazella, Jean, Dix, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908295/
https://ncbi.nlm.nih.gov/pubmed/20481538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100092s
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