The 8 and 5 kDa Fragments of Plasma Gelsolin Form Amyloid Fibrils by a Nucleated Polymerization Mechanism, while the 68 kDa Fragment is Not Amyloidogenic

Familial amyloidosis of Finnish type (FAF), or gelsolin amyloidosis, is a systemic amyloid disease caused by a mutation (D187N/Y) in domain 2 of human plasma gelsolin, resulting in domain 2 misfolding within the secretory pathway. Upon passage through the Golgi, furin endoproteolysis within domain 2...

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Huvudupphovsmän: Solomon, James P., Yonemoto, Isaac T., Murray, Amber N., Price, Joshua L., Powers, Evan T., Balch, William E., Kelly, Jeffery W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907741/
https://ncbi.nlm.nih.gov/pubmed/19904968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901368e
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