Dasatinib reverses Cancer-associated Fibroblasts (CAFs) from primary Lung Carcinomas to a Phenotype comparable to that of normal Fibroblasts

Cancer associated fibroblasts (CAFs) play a critical role for growth, invasion, and metastasis of cancer. Therefore, targeting CAFs with small molecule inhibitors may be an attractive anti-tumor strategy. The current study aims to identify small molecule kinase inhibitors affecting CAF's growth...

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Detalhes bibliográficos
Main Authors: Haubeiss, Silke, Schmid, Jens O, Mürdter, Thomas E, Sonnenberg, Maike, Friedel, Godehard, van der Kuip, Heiko, Aulitzky, Walter E
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907332/
https://ncbi.nlm.nih.gov/pubmed/20579391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-168
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