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Extremely Low Penetrance of Leber’s Hereditary Optic Neuropathy in 8 Han Chinese Families Carrying the ND4 G11778A Mutation
PURPOSE: To investigate the role of mitochondrial haplotypes in the development of Leber’s hereditary optic neuropathy (LHON) associated with the ND4 G11778A mutation in Chinese families. DESIGN: Eight Han Chinese families with maternally transmitted LHON were studied using clinical, genetic, and mo...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2907161/ https://ncbi.nlm.nih.gov/pubmed/19167085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ophtha.2008.10.022 |
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