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Neuronal expression of Mgat1 rescues the shortened life span of Drosophila Mgat1(1) null mutants and increases life span

The enzyme UDP-GlcNAc:α3-D-mannoside β1,2-N-acetylglucosaminyltransferase I (GnT1, encoded by Mgat1) controls the synthesis of paucimannose N-glycans in Drosophila. We have previously reported that null mutations in Drosophila Mgat1 are viable but exhibit defects in locomotion, brain abnormalities,...

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Detalhes bibliográficos
Main Authors: Sarkar, Mohan, Iliadi, Konstantin G., Leventis, Peter A., Schachter, Harry, Boulianne, Gabrielle L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906912/
https://ncbi.nlm.nih.gov/pubmed/20457894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004431107
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