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Neuronal expression of Mgat1 rescues the shortened life span of Drosophila Mgat1(1) null mutants and increases life span
The enzyme UDP-GlcNAc:α3-D-mannoside β1,2-N-acetylglucosaminyltransferase I (GnT1, encoded by Mgat1) controls the synthesis of paucimannose N-glycans in Drosophila. We have previously reported that null mutations in Drosophila Mgat1 are viable but exhibit defects in locomotion, brain abnormalities,...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2906912/ https://ncbi.nlm.nih.gov/pubmed/20457894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004431107 |
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