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A molecular mechanism underlying the neural-specific defect in torsinA mutant mice
A striking but poorly understood feature of many diseases is the unique involvement of neural tissue. One example is the CNS-specific disorder DYT1 dystonia, caused by a 3-bp deletion (“ΔE”) in the widely expressed gene TOR1A. Disease mutant knockin mice (Tor1a(ΔE/ΔE)) exhibit disrupted nuclear memb...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
National Academy of Sciences
2010
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2906867/ https://ncbi.nlm.nih.gov/pubmed/20457914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912877107 |
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