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Essential role of Ubiquitin and TSG101 in formation and function of the central supramolecular activation cluster
Agonist MHC-peptide complexes in the immunological synapse (IS) signal through T cell receptor (TCR) microclusters (MC) that converge into a central supramolecular activation cluster (cSMAC). The determinants and function of the cSMAC remain unknown. We demonstrate an essential role for ubiquitin an...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2905630/ https://ncbi.nlm.nih.gov/pubmed/20399684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.04.005 |
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