Genetic and Maternal Effects on Valproic Acid Teratogenesis in C57BL/6J and DBA/2J Mice

Valproic acid (VPA) is used worldwide to treat epilepsy, migraine headaches, and bipolar disorder. However, VPA is teratogenic and in utero exposure can lead to congenital malformations. Using inbred C57BL/6J (B6) and DBA/2J (D2) mice, we asked whether genetic variation could play a role in suscepti...

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Detalhes bibliográficos
Main Authors: Downing, Chris, Biers, Jami, Larson, Colin, Kimball, Alexi, Wright, Hali, Ishii, Takamasa, Gilliam, David, Johnson, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Reproductive and Developmental Toxicology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905403/
https://ncbi.nlm.nih.gov/pubmed/20457659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq140
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