Mitochondrial tRNA(Thr) G15927A mutation may modulate the phenotypic manifestation of ototoxic 12S rRNA A1555G mutation in four Chinese families

OBJECTIVE: To investigate the role of mitochondrial modifiers in the development of deafness associated with 12S rRNA A1555G mutation. METHODS: Four Chinese families with nonsyndromic and aminoglycoside-induced deafness were studied by clinical and genetic evaluation, molecular and biochemical analy...

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Detalhes bibliográficos
Main Authors: Wang, Xinjian, Lu, Jianxin, Zhu, Yi, Yang, Aifen, Yang, Li, Li, Ronghua, Chen, Bobei, Qian, Yaping, Tang, Xiaowen, Wang, Jindan, Zhang, Xue, Guan, Min-Xin
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905378/
https://ncbi.nlm.nih.gov/pubmed/18820594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e3283131661
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