Trastuzumab induced in vivo tissue remodelling associated in vitro with inhibition of the active forms of AKT and PTEN and RhoB induction in an ovarian carcinoma model

BACKGROUND: The incidence of ovarian cancer has been increasing worldwide and it is currently the leading cause of death from gynaecological malignancy. Unlike breast cancer, the prognostic role of the human epidermal growth factor receptor-2 (HER-2) in ovarian carcinoma remains controversial. METHO...

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Detalhes bibliográficos
Main Authors: Delord, J-P, Quideau, S, Rochaix, P, Caselles, O, Couderc, B, Hennebelle, I, Courbon, F, Canal, P, Allal, B C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905299/
https://ncbi.nlm.nih.gov/pubmed/20588279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605699
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