Abnormal hippocampal functioning and impaired spatial navigation in depressed individuals

OBJECTIVE: Dysfunction of the hippocampus has long been suspected to be a key component of the pathophysiology of major depressive disorder. Despite evidence of hippocampal structural abnormalities in depressed patients, abnormal hippocampal functioning has not been demonstrated. We aimed to link sp...

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Main Authors: Cornwell, Brian R., Salvadore, Giacomo, Colon-Rosario, Veronica, Latov, David R., Holroyd, Tom, Carver, Frederick W., Coppola, Richard, Manji, Husseini K., Zarate, Carlos A., Grillon, Christian
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905217/
https://ncbi.nlm.nih.gov/pubmed/20439387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1176/appi.ajp.2009.09050614
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