A Single Destabilizing Mutation (F9S) Promotes Concerted Unfolding of an Entire Globular Domain in γS-Crystallin

Conformational change and aggregation of native proteins are associated with many serious age-related and neurological diseases. γS-Crystallin is a highly stable, abundant structural component of vertebrate eye lens. A single F9S mutation in the N-terminal domain of mouse γS-crystallin causes the se...

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Main Authors: Lee, Soojin, Mahler, Bryon, Toward, Jodie, Jones, Blake, Wyatt, Keith, Dong, Lijin, Wistow, Graeme, Wu, Zhengrong
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904975/
https://ncbi.nlm.nih.gov/pubmed/20382156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.04.003
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