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Determinants of CREB degradation and KChIP2 gene transcription in cardiac memory

BACKGROUND: Left ventricular pacing (LVP) to induce cardiac memory (CM) in dogs results in a decreased transient outward K current (I(to)) and reduced mRNA and protein of the I(to) channel accessory subunit, KChIP2. The KChIP2 decrease is attributed to a decrease in its transcription factor CREB (cA...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Özgen, Nazira, Lau, David H., Shlapakova, Iryna N., Sherman, Warren, Feinmark, Steven J., Danilo, Peter, Rosen, Michael R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904822/
https://ncbi.nlm.nih.gov/pubmed/20346417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2010.03.024
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