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Sampling the Solution Space in Genome-Scale Metabolic Networks Reveals Transcriptional Regulation in Key Enzymes

Genome-scale metabolic models are available for an increasing number of organisms and can be used to define the region of feasible metabolic flux distributions. In this work we use as constraints a small set of experimental metabolic fluxes, which reduces the region of feasible metabolic states. Onc...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bordel, Sergio, Agren, Rasmus, Nielsen, Jens
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904763/
https://ncbi.nlm.nih.gov/pubmed/20657658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000859
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