MMP-9, uPAR and Cathepsin B Silencing Downregulate Integrins in Human Glioma Xenograft Cells In Vitro and In Vivo in Nude Mice

BACKGROUND: Involvement of MMP-9, uPAR and cathepsin B in adhesion, migration, invasion, proliferation, metastasis and tumor growth has been well established. In the present study, MMP-9, uPAR and cathepsin B genes were downregulated in glioma xenograft cells using shRNA plasmid constructs and we ev...

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Autors principals: Veeravalli, Krishna Kumar, Chetty, Chandramu, Ponnala, Shivani, Gondi, Christopher S., Lakka, Sajani S., Fassett, Daniel, Klopfenstein, Jeffrey D., Dinh, Dzung H., Gujrati, Meena, Rao, Jasti S.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904700/
https://ncbi.nlm.nih.gov/pubmed/20657647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011583
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