Characterization of Structural Changes in Vimentin Bearing an Epidermolysis Bullosa Simplex-like Mutation Using Site-directed Spin Labeling and Electron Paramagnetic Resonance

Mutations in intermediate filament protein genes are responsible for a number of inherited genetic diseases including skin blistering diseases, corneal opacities, and neurological degenerations. Mutation of the arginine (Arg) residue of the highly conserved LNDR motif has been shown to be causative...

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Bibliographic Details
Main Authors: Hess, John F., Budamagunta, Madhu S., FitzGerald, Paul G., Voss, John C.
Format: Artigo
Language:Inglês
Published: 2004
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904505/
https://ncbi.nlm.nih.gov/pubmed/15556930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M412254200
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