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Refractory Colitis Following Anti-CTLA4 Antibody Therapy; Analysis of Mucosal FOXP3+ T Cells

Ipilimumab is a humanized antibody to CTLA4, used to treat cancers refractory to conventional treatment. We treated 21 patients with refractory melanoma or prostate cancer with anti-CTLA4 antibody (ipilimumab), with subsequent development of significant colitis in 9. Two of these nine did not respon...

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Detalhes bibliográficos
Main Authors: Lord, James D., Hackman, Robert C., Moklebust, Amanda, Thompson, John A., Higano, Celestia S., Chielens, Deborah, Steinbach, Gideon, McDonald, George B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904314/
https://ncbi.nlm.nih.gov/pubmed/19507029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10620-009-0839-8
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