J Domain Co-chaperone Specificity Defines the Role of BiP during Protein Translocation

Hsp70 chaperones can potentially interact with one of several J domain-containing Hsp40 co-chaperones to regulate distinct cellular processes. However, features within Hsp70s that determine Hsp40 specificity are undefined. To investigate this question, we introduced mutations into the ER-lumenal Hsp...

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Main Authors: Vembar, Shruthi S., Jonikas, Martin C., Hendershot, Linda M., Weissman, Jonathan S., Brodsky, Jeffrey L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Protein Synthesis and Degradation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903355/
https://ncbi.nlm.nih.gov/pubmed/20430885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.102186
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