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A Caspase Cleaved Form of Tau Is Preferentially Degraded through the Autophagy Pathway
The microtubule-associated protein tau plays a central role in the pathogenesis of Alzheimer disease (AD) and abnormally accumulates as neurofibrillary tangles; therefore, the pathways by which tau is degraded have been examined extensively. In AD brain tau is abnormally truncated at Asp(421) (tauΔC...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2903354/ https://ncbi.nlm.nih.gov/pubmed/20466727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.110940 |
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