Inhibition of In Vivo HIV Infection in Humanized Mice by Gene Therapy of Human Hematopoietic Stem Cells with a Lentiviral Vector Encoding a Broadly Neutralizing Anti-HIV Antibody

Due to the inherent immune evasion properties of the HIV envelope, broadly neutralizing HIV-specific antibodies capable of suppressing HIV infection are rarely produced by infected individuals. We examined the feasibility of utilizing genetic engineering to circumvent the restricted capacity of indi...

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Detalhes bibliográficos
Main Authors: Joseph, Aviva, Zheng, Jian Hua, Chen, Ken, Dutta, Monica, Chen, Cindy, Stiegler, Gabriela, Kunert, Renate, Follenzi, Antonia, Goldstein, Harris
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903239/
https://ncbi.nlm.nih.gov/pubmed/20410262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02339-09
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