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Enhanced Product Stability in the Hammerhead Ribozyme

The rate of dissociation of P1, the 5′ product of hammerhead cleavage, is 100–300-fold slower in full-length hammerheads than in hammerheads that either lack or have disrupting mutations in the loop-loop tertiary interaction. The added stability requires the presence of residue 17 at the 3′ terminus...

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Bibliographic Details
Main Authors: Shepotinovskaya, Irina, Uhlenbeck, Olke C.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903062/
https://ncbi.nlm.nih.gov/pubmed/20423112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902025m
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