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Enhanced Product Stability in the Hammerhead Ribozyme
The rate of dissociation of P1, the 5′ product of hammerhead cleavage, is 100–300-fold slower in full-length hammerheads than in hammerheads that either lack or have disrupting mutations in the loop-loop tertiary interaction. The added stability requires the presence of residue 17 at the 3′ terminus...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2903062/ https://ncbi.nlm.nih.gov/pubmed/20423112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902025m |
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