Rationalisation of the Differences between APOBEC3G Structures from Crystallography and NMR Studies by Molecular Dynamics Simulations

The human APOBEC3G (A3G) protein is a cellular polynucleotide cytidine deaminase that acts as a host restriction factor of retroviruses, including HIV-1 and various transposable elements. Recently, three NMR and two crystal structures of the catalytic deaminase domain of A3G have been reported, but...

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Bibliographic Details
Main Authors: Autore, Flavia, Bergeron, Julien R. C., Malim, Michael H., Fraternali, Franca, Huthoff, Hendrik
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902501/
https://ncbi.nlm.nih.gov/pubmed/20635000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011515
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